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PF 4981517

Cat. No. 4252

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Chemical Name: (1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)

Biological Activity

Potent and selective inhibitor of CYP3A4 (IC₅₀ values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:

456.59

Formula:

C₂₆H₃₂N₈

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

1390637-82-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Walsky et al (2012) Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther. Epub ahead of print.

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