Cat. No. 4250
Chemical Name: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydrox
Biological ActivityType II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Crespi et al (1986) Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 136 521. PMID: 3010982.
Scott and Figgit (2004) Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 18 379. PMID: 15089110.
Wan et al (2013) A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem. 56 2619. PMID: 23442188.
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Keywords: Mitoxantrone dihydrochloride, supplier, topoisomerase, II, inhibitor, inhibits, DNA, topoisomerase, type, II, antitumor, immunosuppressant, DNA, synthesis, repair, PIM1, kinase