R&D Systems Inc. Tocris Bioscience Boston Biochem

Mitoxantrone dihydrochloride

Cat. No. 4250

Mitoxantrone dihydrochloride C22H28N4O6.2HCl [70476-82-3]

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Chemical Name: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

Biological Activity

Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Immunomodulatory, antineoplastic and chemotherapeutic agent.

Technical Data

M.Wt:
517.4
Formula:
C22H28N4O6.2HCl
Solubility:
Soluble to 5 mM in water and to 75 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
70476-82-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Crespi et al (1986) Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 136 521.

Scott and Figgit (2004) Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 18 379. PMID: 15089110.

If you know of a relevant citation for this product please let us know.

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Keywords: Mitoxantrone dihydrochloride, supplier, topoisomerase, II, inhibitor, inhibits, DNA, topoisomerase, type, II, antitumor, immunosuppressant, DNA, synthesis, repair

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