Cat. No. 4241
Chemical Name: (Z)-11-[3-(Dimethylamino)propyliden
Biological ActivityHistamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252.
Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118. PMID: 17962722.
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Keywords: Olopatadine hydrochloride, supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic
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December 16 - 18, 2014
Booth Number: 12