Olopatadine hydrochloride

Cat. No. 4241

Olopatadine hydrochloride C21H23NO3.HCl [140462-76-6]

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Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride

Biological Activity

Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Technical Data

Soluble to 75 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Sharif et al (1996) Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharm.Exp.Ther. 278 1252.

Tamura et al (2007) Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 81 118. PMID: 17962722.

If you know of a relevant citation for this product please let us know.

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Keywords: Olopatadine hydrochloride, supplier, histamine, H1, antagonists, antihistamines, mast, cell, stabilizers, ocular, antiallergic, Histamine H1 Receptor Antagonists

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