Cat. No. 4231
Alternative Names: A-4166, Senaglinide
Chemical Name: N-[[4-(1-Methylethyl)cyclohexyl]car
Biological ActivityKir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+ concentration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shinkai et al (1989) N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 32 1436. PMID: 2738878.
Fujitani et al (1997) The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 120 1191. PMID: 9105692.
Hu et al (1999) Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell KATP channels. J.Pharmacol.Exp.Ther. 291 1372. PMID: 10565863.
Chachin et al (2003) Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels. J.Pharmacol.Exp.Ther. 304 1025. PMID: 12604678.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Nateglinide, supplier, Nateglinide, A4166, senaglinide, antidiabetic, hypoglycemic, hypoglycaemic, KATP, channels, blockers, SUR1/Kir6.2, pancreatic, pancreas, beta-cells, b-cells, β-cells, Inward Rectifier Potassium (Kir) Channel Blockers
Find multiple products by catalog number
New Products in this Area
Potent Kv2.1 and Kv2.2 channel blockerAmmTX3
KV4 channel blockerSpadin
Potent TREK-1 channel blockerLei-Dab 7
High affinity, selective KCa2.2 blockerNS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currents
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.