Cat. No. 4231
Alternative Names: A-4166, Senaglinide
Chemical Name: N-[[4-(1-Methylethyl)cyclohexyl]car
Biological ActivityKir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+ concentration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Shinkai et al (1989) N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of hypoglycemic agents. J.Med.Chem. 32 1436. PMID: 2738878.
Fujitani et al (1997) The ability of a new hypoglycemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition. Br.J.Pharmacol. 120 1191. PMID: 9105692.
Hu et al (1999) Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and β-cell KATP channels. J.Pharmacol.Exp.Ther. 291 1372. PMID: 10565863.
Chachin et al (2003) Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic β-cell-type KATP channels. J.Pharmacol.Exp.Ther. 304 1025. PMID: 12604678.
If you know of a relevant citation for this product please let us know.
Keywords: Nateglinide, supplier, Nateglinide, A4166, senaglinide, antidiabetic, hypoglycemic, hypoglycaemic, KATP, channels, blockers, SUR1/Kir6.2, pancreatic, pancreas, beta-cells, b-cells, β-cells
Find multiple products by catalog number
New Products in this Area
Potent and selective Iks channel blockerNS 19504
Activator of BKCa (KCa1.1) channelsTRAM 39
Potent KCa3.1 blockerBDS I
Potent and reversible Kv3.4 potassium channel blocker; neuroprotectiveAgitoxin 2
Potent Shaker K+ channel blocker
One Day Symposium
March 17, 2015