R&D Systems Inc. Tocris Bioscience Boston Biochem

Valsartan

Cat. No. 4216

Valsartan C24H29N5O3 [137862-53-4]

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Alternative Name: CGP 48933

Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid

Biological Activity

High affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.

Technical Data

M.Wt:
435.52
Formula:
C24H29N5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
137862-53-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Criscione et al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761. PMID: 8242249.

Wexler et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625. PMID: 8576904.

Hanafy et al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90. PMID: 17965735.

If you know of a relevant citation for this product please let us know.

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Keywords: Valsartan, supplier, Valsartan, CGP48933, atII, receptors, atI, angiotensin1, angiotensinI, receptors, antagonists, selective

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