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ValsartanCat. No. 4216 |
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Alternative Name: CGP 48933 Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid |
Biological Activity
High affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.Certificate of Analysis / Safety Data Sheet
References
Criscione et al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761. PMID: 8242249.
Wexler et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625. PMID: 8576904.
Hanafy et al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90. PMID: 17965735.
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Keywords: Valsartan, supplier, Valsartan, CGP48933, atII, receptors, atI, angiotensin1, angiotensinI, receptors, antagonists, selective
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