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ValdecoxibCat. No. 4206 |
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Chemical Name: 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide |
Biological Activity
Selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Certificate of Analysis / Safety Data Sheet
References
Talley et al (2000) 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 43 775. PMID: 10715145.
Walker et al (2001) A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 357 709. PMID: 11463341.
Gierse et al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 312 1206. PMID: 15494548.
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Keywords: Valdecoxib, supplier, cyclooxygenase-2, COX-2, inhibitors, selective, potent, NSAIDs, pfizer, non-steroidal, anti-inflammatory
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