R&D Systems Inc. Tocris Bioscience Boston Biochem

Valdecoxib

Cat. No. 4206

Valdecoxib C16H14N2O3S [181695-72-7]

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Chemical Name: 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide

Biological Activity

Selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
314.36
Formula:
C16H14N2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
181695-72-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Talley et al (2000) 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 43 775. PMID: 10715145.

Walker et al (2001) A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 357 709. PMID: 11463341.

Gierse et al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 312 1206. PMID: 15494548.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Valdecoxib, supplier, cyclooxygenase-2, COX-2, inhibitors, selective, potent, NSAIDs, pfizer, non-steroidal, anti-inflammatory

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