R&D Systems Inc. Tocris Bioscience Boston Biochem

BTZO 1

Cat. No. 4204

BTZO 1 C13H8N2OS [99420-15-2]

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Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one

Biological Activity

Macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.

Technical Data

M.Wt:
240.28
Formula:
C13H8N2OS
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
99420-15-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282. PMID: 21168764.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: BTZO 1, supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective

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