Cat. No. 4184
Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethy
Biological ActivityInhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465. PMID: 18536749.
Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459. PMID: 20051879.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: Torcetrapib, supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Tocris Bioscience, Lipid Metabolism Inhibitors
Find multiple products by catalog number
New Products in this Area
Potent inhibitor of Aβ oligomer and fibril formationLDN 193188
Inhibitor of phosphatidylcholine transfer protein (PC-TP)Hydroxychloroquine sulfate
Autophagy inhibitor; also TLR9 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.