KU 60019

Cat. No. 4176

KU 60019 C30H33N3O5S [925701-46-8]

Price and Availability

For KU 60019 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide

Biological Activity

Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.

Licensing Information

Sold with the permission of AstraZeneca.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Golding et al (2009) Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol.Cancer Ther. 8 2894. PMID: 19808981.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: KU 60019, supplier, Astrazeneca, KU60019, atm, kinases, ataxia, telangiectasia, mutated, potent, inhibitors, ATM and ATR Kinase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

Cell Cycle Life Science Poster

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis. Request copy today.

divider line

New Products in this Area

KG 5

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor


Syk kinase inhibitor; inhibits Aβ production

Centrinone B

High affinity and selective PLK4 inhibitor

HTH 01-015

Potent and selective NUAK1 inhibitor

Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

OSU 03012

PDK1 inhibitor; inhibits Akt signaling

SR 7826

Potent and selective LIMK inhibitor; antitumor

Mps BAY 2a

Potent and selective Mps1 kinase inhibitor

NG 25

TGF-β-activated kinase (TAK1) inhibitor

MI 14

Potent and selective PI 4-kinase IIIβ inhibitor

CTA 056

ITK inhibitor

AZD 1480

Potent and selective JAK2 inhibitor; antiangiogenic

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

BS 181 dihydrochloride

Selective cdk7 inhibitor


Potent and selective PI 3-kinase p110α inhibitor

AZ 191

Potent DYRK1B inhibitor

ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

PFK 15

PFKFB3 inhibitor

PD 0332991 isethionate

Potent, selective Cdk4/6 inhibitor; brain penetrant

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.