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KU 60019

Cat. No. 4176

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Chemical Name: (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide

Biological Activity

Potent ATM kinase inhibitor (IC₅₀ = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.

Licensing Information

Sold with the permission of AstraZeneca.

Technical Data

M.Wt:

547.67

Formula:

C₃₀H₃₃N₃O₅S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

925701-46-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Golding et al (2009) Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol.Cancer Ther. 8 2894. PMID: 19808981.

If you know of a relevant citation for this product please let us know.

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