PF 3845

Cat. No. 4175

PF 3845 C24H23F3N4O2 [1196109-52-0]

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Chemical Name: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide

Biological Activity

Selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Ahn et al (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 16 411. PMID: 19389627.

Ahn et al (2009) Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 4 763. PMID: 20544003.

If you know of a relevant citation for this product please let us know.

Keywords: PF 3845, supplier, pfizer, cannabinoid, receptors, fatty, acid, amide, hydrolase, FAAH, inhibitors, PF3845

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