Cat. No. 1510
Alternative Name: OKY 046
Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)p
Biological ActivityPotent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41. PMID: 6413227.
Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393. PMID: 3093741.
Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266. PMID: 10991919.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Ozagrel hydrochloride, supplier, Selective, thromboxane, A2, synthetase, inhibitors, Thromboxane, TP, Prostanoid, Synthases, Synthetases, prostaglandins, prostacyclins, eicosanoids, OKY046
Find multiple products by catalog number
New Products in this Area
Potent GPR37 and GPR37L1 agonistAS 2034178
Selective FFA1 (GPR40) agonist(±)-NBI 74330
Potent and selective CXCR3 antagonistPurmorphamine
Smo receptor agonistCTCE 9908
CXCR4 antagonist; antitumorVUF 11207 fumarate
Potent CXCR7 agonistTC-G 1006
Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonistDMNPE-caged ATP diammonium salt
Caged ATPMK 1903
Potent and selective GPR109A (HCA2) agonistM 25
Potent Smoothened (Smo) receptor antagonist
July 23 - 27, 2014
Bonn University, Germany