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GSK 690693

Cat. No. 4144

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Special Conditions

No more than 500 mg per individual per year to be sold without prior permission from the licence holder.

Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

Biological Activity

ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC₅₀ < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Technical Data

M.Wt:

425.48

Formula:

C₂₁H₂₇N₇O₃

Solubility:

Soluble to 50 mM in DMSO

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

937174-76-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Heerding et al (2008) Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 51 5663. PMID: 18800763.

Rhodes et al (2008) Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 68 2366. PMID: 18381444.

If you know of a relevant citation for this product please let us know.

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Keywords: GSK 690693, supplier, GSK, 690693, inhibits, Akt, inhibitor, GSK690693, antitumor, antiproliferative

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