R&D Systems Inc. Tocris Bioscience Boston Biochem

Salermide

Cat. No. 4127

Salermide C26H22N2O2 [1105698-15-4]

Price and Availability

For Salermide pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide

Biological Activity

SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.

Technical Data

M.Wt:
394.47
Formula:
C26H22N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1105698-15-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789. PMID: 16302818.

Lara et al (2009) Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28 781. PMID: 19060927.

Pasco et al (2010) Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. J.Med.Chem. 53 1407. PMID: 20041717.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Salermide, supplier, sirt1, sirt2, sirtuin, sir2-like, inhibitors, apoptosis, proapoptotic, antitumor, agents

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

FK 228

Potent and selective class I histone deacetylase inhibitor; antitumor

Sign-up for new product e-alerts
divider line

Tocris Events

Meet your representative

R&D Symposium 2014

Molecular Mechanisms in Signal Transduction

July 15, 2014

Cambridge, UK