Cat. No. 4112
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicot
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272. PMID: 7535111.
Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. PMID: 9427063.
Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579. PMID: 19888597.
Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373. PMID: 22523636.
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Keywords: Niflumic acid, supplier, cyclooxygenase, 2, cox-2, inhibitors
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April 12 - 15, 2015