R&D Systems Inc. Tocris Bioscience Boston Biochem

Niflumic acid

Cat. No. 4112

Niflumic acid C13H9F3N2O2 [4394-00-7]

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Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Technical Data

M.Wt:
282.22
Formula:
C13H9F3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at RT
CAS No:
4394-00-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272. PMID: 7535111.

Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. PMID: 9427063.

Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579. PMID: 19888597.

Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373. PMID: 22523636.

If you know of a relevant citation for this product please let us know.

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Keywords: Niflumic acid, supplier, cyclooxygenase, 2, cox-2, inhibitors

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