SU 11274

Cat. No. 4101

SU 11274 C28H30ClN5O4S [658084-23-2]

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Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Biological Activity

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

Technical Data

M.Wt:
568.09
Formula:
C28H30ClN5O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
658084-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462. PMID: 14500382.

Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085. PMID: 14617781.

Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021. PMID: 19318576.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: SU 11274, supplier, SU11274, Supplier, c-Met, inhibitor, inhibits, MET, tyrosine, kinase, activity, met, receptors, Tocris Bioscience, MET Receptor Inhibitors

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