R&D Systems Inc. Tocris Bioscience Boston Biochem

SU 11274

Cat. No. 4101

SU 11274 C28H30ClN5O4S [658084-23-2]

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Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Biological Activity

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

Technical Data

M.Wt:
568.09
Formula:
C28H30ClN5O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
658084-23-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462. PMID: 14500382.

Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085. PMID: 14617781.

Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021. PMID: 19318576.

If you know of a relevant citation for this product please let us know.

Keywords: SU 11274, supplier, SU11274, Supplier, c-Met, inhibitor, inhibits, MET, tyrosine, kinase, activity, met, receptors

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