Cat. No. 4101
Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dim
Biological ActivitySelective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462. PMID: 14500382.
Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085. PMID: 14617781.
Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021. PMID: 19318576.
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Keywords: SU 11274, supplier, SU11274, Supplier, c-Met, inhibitor, inhibits, MET, tyrosine, kinase, activity, met, receptors, Tocris Bioscience, MET Receptor Inhibitors
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