Cat. No. 4088
Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-
Biological ActivitySelective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179. PMID: 20829789.
Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110. PMID: 20823120.
If you know of a relevant citation for this product please let us know.
Keywords: IU1, supplier, selective, usp14, inhibitors, proteasome, substrate, degradation
Find multiple products by catalog number
New Products in this Area
Insulin-regulated aminopeptidase (IRAP) inhibitorSSM 3 trifluoroacetate
Potent furin inhibitor(Z-LL)2 ketone
Putative inhibitor of signal peptide peptidasePR 619
Broad spectrum DUB inhibitorTC-E 5007
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitorSD 2590 hydrochloride
Potent MMP inhibitorAliskiren hemifumarate
Potent renin inhibitor; antihypertensive
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.