IU1

Cat. No. 4088

IU1 C18H21FN2O [314245-33-5]

Price and Availability

For IU1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone

Biological Activity

Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.

Technical Data

M.Wt:
300.37
Formula:
C18H21FN2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
314245-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179. PMID: 20829789.

Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110. PMID: 20823120.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: IU1, supplier, selective, usp14, inhibitors, proteasome, substrate, degradation, Tocris Bioscience, Deubiquitinating Enzyme Inhibitors

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

VTP 27999 trifluoroacetate

Highly potent and selective renin inhibitor

Tiplaxtinin

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Balicatib

Potent and selective cathepsin K inhibitor

HFI 142

Insulin-regulated aminopeptidase (IRAP) inhibitor

Sign-up for new product e-alerts
divider line

FENS 2016

Win a $1,000 travel grant

FENS Travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for FENS 2016.