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IU1Cat. No. 4088 |
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Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone |
Biological Activity
Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 μM). Stimulates proteasome activity and substrate degradation.Certificate of Analysis / Safety Data Sheet
References
Lee et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467 179. PMID: 20829789.
Lee et al (2010) Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol.Cell.Proteomics 10 R110. PMID: 20823120.
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Keywords: IU1, supplier, selective, usp14, inhibitors, proteasome, substrate, degradation
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