P7C3

Cat. No. 4076

P7C3 C21H18Br2N2O [301353-96-8]

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Chemical Name: 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol

Biological Activity

NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.

Technical Data

M.Wt:
474.19
Formula:
C21H18Br2N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
301353-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Pieper et al (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142 39. PMID: 20603013.

Wang et al (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158 1324. PMID: 25215490.

If you know of a relevant citation for this product please let us know.

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Keywords: P7C3, supplier, P7C3, neuroprotective, neurogenesis, proneurogenic, Tocris Bioscience, NAMPT Activators

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