TC-A 2317 hydrochloride

Cat. No. 4066

TC-A 2317 hydrochloride C19H28N6O.HCl [1245907-03-2]

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Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

Biological Activity

Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data

M.Wt:
392.93
Formula:
C19H28N6O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1245907-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709. PMID: 20573509.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TC-A 2317 hydrochloride, supplier, inhibits, aurora, kinase, a, inhibitor, antitumor, Aurora, A

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