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TC-A 2317 hydrochloride

Cat. No. 4066

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Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

Biological Activity

Potent Aurora kinase A inhibitor (K_i = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC₅₀ values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data

M.Wt:

392.93

Formula:

C₁₉H₂₈N₆O.HCl

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

1245907-03-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709. PMID: 20573509.

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Keywords: TC-A 2317 hydrochloride, supplier, inhibits, aurora, kinase, a, inhibitor, antitumor, Aurora, A

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