R&D Systems Inc. Tocris Bioscience Boston Biochem

TC-A 2317 hydrochloride

Cat. No. 4066

TC-A 2317 hydrochloride C19H28N6O.HCl [1245907-03-2]

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Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride

Biological Activity

Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data

M.Wt:
392.93
Formula:
C19H28N6O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1245907-03-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709. PMID: 20573509.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: TC-A 2317 hydrochloride, supplier, inhibits, aurora, kinase, a, inhibitor, antitumor, Aurora, A

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