Cat. No. 4061
Alternative Name: 6-TG
Chemical Name: 2-Amino-6-mercaptopurine
Biological ActivityAnticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wang and Wang (2009) 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 48 2290. PMID: 19236003.
Issaeva et al (2010) 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 70 6268. PMID: 20631063.
Yuan et al (2011) 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res. 71 1904. PMID: 21239472.
If you know of a relevant citation for this product please let us know.
Keywords: 6-Thioguanine, supplier, 6-TG, anticancer, chemotherapeutics, immunosupprressive, agents, cytotoxic, antineoplastic, cancer, BRCA2, tumors, epigenetics, antimetabolites
Find multiple products by catalog number
New Products in this Area
AntibioticAmpicillin sodium salt
Antibiotic; selection reagentBlasticidin S HCl
Antibiotic; selection reagent for bis, bsr and BSD transformed cellsCORM 3
Water-soluble carbon monoxide-releasing molecule
September 5 - 8, 2015