R&D Systems Inc. Tocris Bioscience Boston Biochem

Docetaxel

Cat. No. 4056

Docetaxel C43H53NO14 [114977-28-5]

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Chemical Name: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Biological Activity

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Technical Data

M.Wt:
807.88
Formula:
C43H53NO14
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
114977-28-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lyseng-Williamson and Fenton (2005) Docetaxel: a review of its use in metastatic breast cancer. Drugs 65 2513. PMID: 16296875.

Ramaswamy and Puhalla (2006) Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 42 265. PMID: 16703123.

If you know of a relevant citation for this product please let us know.

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Keywords: Docetaxel, supplier, cancer, therapy, antitumor, binds, stabilizes, microtubules, microtubule, stabilizer

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