Cat. No. 4045
Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butyl ester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide
Biological ActivityProteasome inhibitor; inhibits chymotrypsin-like activity of the proteasome. Causes dopaminergic cell death in vitro. Prevents activation of NF-κB in response to TNF-α and okadaic acid (Cat. No. 1136) by inhibiting IκB-α degradation. Also inhibits NO production by LPS-activated macrophages.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Traenckner et al (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13 5433. PMID: 7957109.
Griscavage et al (1996) Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93 3308.
Bukhatwa et al (2009) An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. J.Neurochem. 109 52. PMID: 19187437.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: PSI, supplier, proteasome, inhibitors, inhibits, Nuclear, Factor, Kappa, B, NF-κB, NF-kappaB, NF-kB, activation
Find multiple products by catalog number
New Products in this Area
γ-secretease inhibitor; inhibits Notch pathwayCA 074
Selective cathepsin B inhibitorP005091
Win a Kindle
June 3 - 5, 2013
Booth Number: C54