R&D Systems Inc. Tocris Bioscience Boston Biochem

PSC 833

Cat. No. 4042

PSC 833 C63H111N11O12 [121584-18-7]

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Alternative Name: Valspodar

Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A

Biological Activity

P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Technical Data

M.Wt:
1214.62
Formula:
C63H111N11O12
Solubility:
Soluble to 4 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
121584-18-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Song et al (1998) Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 287 963. PMID: 9864280.

Goda et al (2007) Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 320 81. PMID: 17050779.

Shen et al (2008) Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 324 95. PMID: 17947497.

Shen et al (2009) Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 330 423. PMID: 19423841.

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View Related Products by Target

Keywords: PSC 833, supplier, PSC833, P-glycoprotein, inhibitors, inhibits, P-gp, cyclosporin, A, analog, analogue, ABCB1

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