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Mycophenolic acid

Cat. No. 1505

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Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Biological Activity

Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

Technical Data

M.Wt:

320.34

Formula:

C₁₇H₂₀O₆

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

24280-93-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161. PMID: 1826793.

Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63. PMID: 7906496.

Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143. PMID: 7482723.

Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537. PMID: 9422796.

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499. PMID: 9087409.

Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007. PMID: 9694962.

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