Cat. No. 4033
Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Biological ActivityInhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FMT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
Licensing InformationSold under licence from Anygen Co. Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253. PMID: 17200363.
Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466. PMID: 18824607.
Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033. PMID: 20153646.
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Keywords: 5'-Fluoroindirubinoxime, supplier, FMS-like, receptor, tyrosine, kinase-3, FLT3, inhibitors, antiproliferative, 5-Fluoroindirubinoxime
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