Home » Pharmacology » Enzyme-Linked Receptors » Receptor Tyrosine Kinases (RTKs) » FLT3 » 5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime

Cat. No. 4033

Price and Availability

For 5'-Fluoroindirubinoxime pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime

Biological Activity

Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC₅₀ = 15 nM). Displays selectivity for FMT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Technical Data

M.Wt:

295.27

Formula:

C₁₆H₁₀FN₃O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

861214-33-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253. PMID: 17200363.

Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466. PMID: 18824607.

Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033. PMID: 20153646.

If you know of a relevant citation for this product please let us know.