Cat. No. 4000
Chemical Name: N-[cis-4-[(4-Chlorophenyl)sulfonyl]
Biological Activityγ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
Licensing InformationManufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Best et al (2006) In vivo characterization of Aβ(40) changes in brain and cerebrospinal fluid using the novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat. J.Pharm.Exp.Ther. 317 786. PMID: 16443723.
Best et al (2007) The novel γ-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of Notch-related pathology in the Tg2576 mouse. J.Pharm.Exp.Ther. 320 552. PMID: 17099072.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: MRK 560, supplier, MRK560, gamma-secretase, inhibitor, g-secretase, inhibitors, secretases, amyloidbeta, amyloidb, amyloidβ
Find multiple products by catalog number
New Products in this Area
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitorSD 2590 hydrochloride
Potent MMP inhibitorAliskiren hemifumarate
Potent renin inhibitor; antihypertensiveSpautin 1
USP10 and USP13 inhibitor; inhibits autophagy
July 4 - 9, 2015