Home » Pharmacology » Enzymes » Dehydrogenases » Aldehyde Dehydrogenase » Alda 1

Alda 1

Cat. No. 4005

Price and Availability

For Alda 1 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

Biological Activity

Activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

Technical Data

M.Wt:

324.16

Formula:

C₁₅H₁₁Cl₂NO₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

349438-38-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493. PMID: 18787169.

Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitroglycerin and effects of alda-1. J.Biol.Chem. 285 943. PMID: 19906643.

If you know of a relevant citation for this product please let us know.