Cat. No. 4005
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Biological ActivityActivator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493. PMID: 18787169.
Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitroglycerin and effects of alda-1. J.Biol.Chem. 285 943. PMID: 19906643.
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Keywords: Alda 1, supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1