EB 1089

Cat. No. 3993

EB 1089 C30H46O3 [134404-52-7]

Price and Availability

For EB 1089 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Seocalcitol

Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

Biological Activity

Vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Technical Data

Soluble in DMSO and in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Abdaimi et al (1999) Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer. Cancer Res, 59 3325.

Hoyer-Hansen et al (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12 1297. PMID: 15905882.

Lu et al (2008) Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol.Cancer Ther. 7 1268. PMID: 18483314.

Ormerod et al (2008) The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp.Lung.Rs. 34 155.

Bhatia et al (2009) EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol.Cancer Ther. 8 1787. PMID: 19584236.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: EB 1089, supplier, EB1089, VDR, agonist, Vitamin, D, receptors, seocalcitol, VDR-like, Vitamin D Receptor Agonists

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

New Products in this Area

Liothyronine sodium

Thyroid hormone (T3) analog; also promotes adipogenic differentiation of MSCs


Potent CAR antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2015

Stem Cells & Organoids as Models of Tissue Differentiation & Disease

January 12, 2016

London, UK