R&D Systems Inc. Tocris Bioscience Boston Biochem

Nutlin-3

Cat. No. 3984

Nutlin-3 C30H30Cl2N4O4 [548472-68-0]

Price and Availability

For Nutlin-3 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Biological Activity

MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Licensing Information

Sold under license from F. Hoffmann-La Roche Ltd.

Technical Data

M.Wt:
581.49
Formula:
C30H30Cl2N4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
548472-68-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844. PMID: 14704432.

If you know of a relevant citation for this product please let us know.

Keywords: Nutlin-3, supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2

Quick Order

Find multiple products by catalog number

divider line

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Poster

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.

divider line

The p53 Tumor Suppressor Response

Written by Christopher J. Brown et al

p53 Poster

A summary of the main strategies that may be utilized to reactivate p53 including several small molecules and peptides which act to stabilize p53 and rescue wild-type activity.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

PTC 209

Bmi-1 inhibitor; antitumor

NSC 624206

Ubiquitin-activating enzyme (E1) inhibitor

SZL P1-41

Selective Skp2 inhibitor; suppresses E3 ligase activity

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Neuroscience 2014

Neuroscience 2014

November 15 - 19, 2014

Washington D.C., USA