Cat. No. 3984
Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-
Biological ActivityMDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Licensing InformationSold under license from F. Hoffmann-La Roche Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844. PMID: 14704432.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Nutlin-3, supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2
Find multiple products by catalog number
New Products in this Area
Ubiquitin-activating enzyme (E1) inhibitorStoppin 2
Competitive p53-MDM2/MDMX interaction inhibitorPRT 4165
Inhibitor of Bmi1/Ring1ANSC 697923
Selective inhibitor of E2 ubiquitin-conjugating enzyme Ubc13-Uev1ANSC 697923
Selective inhibitor of E2 ubiquitin-conjugating enzyme Ubc13-Uev1A
June 28 - July 3, 2014