R&D Systems Inc. Tocris Bioscience Boston Biochem

Alexidine dihydrochloride

Cat. No. 3979

Alexidine dihydrochloride C26H56N10.2HCl [1715-30-6]

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Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride

Biological Activity

Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells.

Technical Data

M.Wt:
581.71
Formula:
C26H56N10.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
1715-30-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Coburn et al (1978) In vitro antiplaque properties of a series of alkyl bis(biguanides). J.Med.Chem. 21 828. PMID: 691009.

Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234. PMID: 16985057.

Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584. PMID: 20167843.

If you know of a relevant citation for this product please let us know.

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Keywords: Alexidine dihydrochloride, supplier, protein, tyrosine, phosphatases, PTP, localized, localised, to, mitochondrion, 1, PTPMT1, inhibitors

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