Alexidine dihydrochloride

Cat. No. 3979

Alexidine dihydrochloride C26H56N10.2HCl [1715-30-6]

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Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride

Biological Activity

Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234. PMID: 16985057.

Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584. PMID: 20167843.

Liu et al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562. PMID: 25593337.

If you know of a relevant citation for this product please let us know.

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Keywords: Alexidine dihydrochloride, supplier, protein, tyrosine, phosphatases, PTP, localized, localised, to, mitochondrion, 1, PTPMT1, inhibitors, stem, cells, Protein Tyrosine Phosphatase Inhibitors

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