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Alexidine dihydrochloride

Cat No. 3979

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Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraaza tetradecanediimidamide dihydrochloride

Biological Activity

Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC₅₀ = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells.

Technical Data

M.Wt:

581.71

Formula:

C₂₆H₅₆N₁₀.2HCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Desiccate at -20°C

CAS No:

[1715-30-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Coburn et al (1978) In vitro antiplaque properties of a series of alkyl bis(biguanides). J.Med.Chem. 21 828. Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234. Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584.

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