Cat. No. 3979
Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-
Biological ActivitySelective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Coburn et al (1978) In vitro antiplaque properties of a series of alkyl bis(biguanides). J.Med.Chem. 21 828. PMID: 691009.
Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234. PMID: 16985057.
Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584. PMID: 20167843.
If you know of a relevant citation for this product please let us know.
Keywords: Alexidine dihydrochloride, supplier, protein, tyrosine, phosphatases, PTP, localized, localised, to, mitochondrion, 1, PTPMT1, inhibitors
Find multiple products by catalog number
New Products in this Area
Potent and selective allosteric inhibitor of Wip1 phosphataseVO-OHpic
Potent PTEN inhibitor
May 19 - 22, 2015