Home » Pharmacology » Other Pharmacology » Miscellaneous Compounds » Deoxynivalenol

Deoxynivalenol

Cat No. 3976

Price and Availability

For Deoxynivalenol pricing & availability please select your country from the drop down menu:
Submit

Alternative Names: DON, Vomitoxin

Chemical Name: 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one

Biological Activity

Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Technical Data

M.Wt:

296.32

Formula:

C₁₅H₂₀O₆

Solubility:

Soluble to 30 mM in ethanol

Storage:

Store at +4°C

CAS No:

[51481-10-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Material Safety Data Sheet: View current batch

References

Bae & Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59. Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247. Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and cyclo-oyxgenase-2 expression. Free Radic.Biol.Med. 49 50.

If you know of a useful citation for this product please let us know.