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Zearalenone

Cat No. 3975

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Chemical Name: (3S,11E)-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methy l-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Biological Activity

Mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC₅₀ values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells.

Technical Data

M.Wt:

318.36

Formula:

C₁₈H₂₂O₅

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at -20°C

CAS No:

[17924-92-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Kuiper et al (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139 4252. Takemura et al (2007) Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J.Steroid Biochem.Molec.Biol. 103 170. Khosrokhavar et al (2009) Effects of zearalenone and alpha-Zearalenol in comparison with Raloxifene on T47D cells. Toxicol.Mech.Methods 19 246.

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