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GPi 688

Cat. No. 3967

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Chemical Name: 2-Chloro-N-[1-[(2R)-2,3-dihydroxypropyl]-1,2,3,4-tetrahydro-2-oxo-3-quinolinyl]-6H-thieno[2,3-b]pyrrole-5-carboxamide

Biological Activity

Allosteric glycogen phosphorylase inhibitor; acts at the indole site of glycogen phosphorylase. Inhibits glucagon-mediated hyperglycemia in vivo in the rat.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:

419.88

Formula:

C₁₉H₁₈ClN₃O₄S

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

918902-32-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Freeman et al (2006) Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme. Br.J.Pharmacol. 149 775. PMID: 17016495.

Poucher et al (2007) An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia. Br.J.Pharmacol. 152 1239. PMID: 17934512.

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