TerfenadineCat No.
3948
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Price and Availability |
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Chemical Name: a-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethy l)-1-piperidinebutanol |
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Biological Activity
Histamine H1 receptor antagonist. Also blocks hERG and KATP channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Crumb (2000) Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions. J.Pharmacol.Exp.Ther. 292 261. Zunkler et al (2000) Mechanism of terfenadine block of ATP-sensitive K+ channels. Br.J.Pharmacol. 130 1571. Stork et al (2007) State dependent dissociation of HERG channel inhibitors. Br.J.Pharmacol. 151 1368If you know of a useful citation for this product please let us know.
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Keywords: Terfenadine, hERG, Human, Ether-A-Go-Go, Gene, K+, channel, blockers, histamine, H1, antagonists, histaminergic, Potassium, KV, KATP, Channels, voltage-gated, voltage-dependent, Receptors
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