TCS 1205Cat No.
3941
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Price and Availability |
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Chemical Name: 5-Nitro-a-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide |
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Biological Activity
GABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Primofiore et al (2001) Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 44 2286. Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-a (GABAa) alpha2 benzodiazepine receptor. J.Med.Chem. 52 3723.If you know of a useful citation for this product please let us know.
Keywords: TCS 1205, TCS1205, GABAA, receptors, subtype-selective
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Modulators of Peripheral Sensitization
Written by M.R. Vasko and G.D. Nicol
'Pharmacological Modulators of Peripheral Sensitization' summarizes the inhibitory and excitatory modulators of peripheral sensitization.
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