TCS 5861528Cat No.
3938
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Price and Availability |
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Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7 -yl)-N-[4-(1-methylpropyl)phenyl]acetamide |
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Biological Activity
TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). Attenuates diabetic hypersensitivity in in vivo rat model.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Wei et al (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111 147. Wei et al (2010) Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58 578. Wei et al (2010) Spinal TRPA1 ion channels contribute to the cutaneous neurogenic inflammation in the rat. Neurosci.Letts. in press.If you know of a useful citation for this product please let us know.
Keywords: TCS 5861528, Selective, TRPA1, blockers, antagonists, Channels, Transient, Receptor, Potential, HC030031
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Modulators of Peripheral Sensitization
Written by M.R. Vasko and G.D. Nicol
'Pharmacological Modulators of Peripheral Sensitization' summarizes the inhibitory and excitatory modulators of peripheral sensitization.
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