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Benidipine hydrochloride

Cat No. 3934

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Alternative Name: KW 3049

Chemical Name: (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5 -pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca²⁺ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Technical Data

M.Wt:

542.02

Formula:

C₂₈H₃₁N₃O₆.HCl

Solubility:

Soluble to 75 mM in DMSO and to 10 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

[91599-74-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243. Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49.

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Keywords: Benidipine hydrochloride, L-type, T-type, N-type, calcium, channels, Ca2+, blockers, inhibitors, selective, voltage-gated, voltage-dependent, CaV, mineralocorticoid, receptor, antagonist

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