SC 236Cat No.
3919
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Price and Availability |
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Alternative Name: SC58236 Chemical Name: 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl] benzenesulfonamide |
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Biological Activity
Selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.Licensing Information
Sold for research purposes under agreement from Pfizer IncTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810. Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359. Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347.If you know of a useful citation for this product please let us know.
Keywords: SC 236, SC236, selective, cyclooxygenase-2, COX-2, inhibitors, Pfizer
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