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S 18986Cat. No. 3911 |
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Chemical Name: 2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide |
Biological Activity
Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.Certificate of Analysis / Safety Data Sheet
References
Desos et al (1996) Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator. Bioorg.Med.Chem.Lett. 6 3003.
Lockhart et al (2000) (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur.J.Pharmacol. 401 145. PMID: 10924919.
Bourasset et al (2005) Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab.Dispos. 33 1137. PMID: 15860654.
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Keywords: S 18986, supplier, S18986, pam, positive, allosteric, modulators, potentiators, ampa, cognitive, enhancers, enhancement, brain, penetrant, bbb
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