R&D Systems Inc. Tocris Bioscience Boston Biochem

API-1

Cat. No. 3897

API-1 C13H15N5O6 [36707-00-3]

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Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

Biological Activity

Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Technical Data

M.Wt:
337.29
Formula:
C13H15N5O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>96 %
Storage:
Store at RT
CAS No:
36707-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Kim et al (2010) A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J.Biol.Chem. 285 8383. PMID: 20068047.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: API-1, supplier, protein, kinase, b, pkb, akt, inhibitors, antitumor, antitumour

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