Cat. No. 3897
Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribo
Biological ActivityAkt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Displays antitumor activity in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kim et al (2010) A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J.Biol.Chem. 285 8383. PMID: 20068047.
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Keywords: API-1, supplier, protein, kinase, b, pkb, akt, inhibitors, antitumor, antitumour
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