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NS 309

Cat. No. 3895

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Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime

Biological Activity

Positive modulator of small- and intermediate- conductance Ca²⁺-activated K⁺ channels (K_Ca2 and K_Ca3.1 channels); increases Ca²⁺ sensitivity. Displays no activity at BK channels.

Technical Data

M.Wt:

231.04

Formula:

C₈H₄Cl₂N₂O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

18711-16-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Strobaek et al (2004) Activation of human IK and SK Ca²⁺-activated K⁺ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta 1665 1. PMID: 15471565.

Morimura et al (2006) Voltage-dependent Ca²⁺-channel block by openers of intermediate and small conductance Ca²⁺-activated K⁺ channels in urinary bladder smooth muscle cells. J.Pharm.Sci. 100 237.

Grgic et al (2009) Endothelial Ca²⁺-activated K⁺ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol. 157 509. PMID: 19302590.

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Keywords: NS 309, supplier, NS309, Ca2+-activated, potassium, K+, KCa, channels, activators, positive, modulators, small, intermediate, conductance, SK, IK, KCa2, KCa3