NS 309Cat No.
3895
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Price and Availability |
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Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione 3-oxime |
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Biological Activity
Positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (SK and IK channels); increases Ca2+ sensitivity. Displays no activity at BK channels.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Grgic et al (2009) Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol. 157 509. Morimura et al (2006) Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. J.Pharm.Sci. 100 237. Strobaek et al (2004) Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta 1665 1.If you know of a useful citation for this product please let us know.
Keywords: NS 309, NS309, Ca2+-activated, potassium, K+, KCa, channels, activators, positive, modulators, small, intermediate, conductance, SK, IK
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