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GANT 58Cat. No. 3889 |
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Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene |
Biological Activity
GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.Certificate of Analysis / Safety Data Sheet
References
Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455. PMID: 17494766.
Beauchamp et al (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 284 9074. PMID: 19189974.
Joo et al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608. PMID: 19859563.
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Keywords: GANT 58, supplier, GANT58, GLI1, inhibits, inhibitors, downstream, Hedgehog, signalling, signaling, Gli, antagonists, Hh
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