R&D Systems Inc. Tocris Bioscience Boston Biochem

GANT 58

Cat. No. 3889

GANT 58 C24H16N4S [64048-12-0]

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Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene

Biological Activity

GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.

Technical Data

M.Wt:
392.48
Formula:
C24H16N4S
Solubility:
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
64048-12-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455. PMID: 17494766.

Beauchamp et al (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 284 9074. PMID: 19189974.

Joo et al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608. PMID: 19859563.

If you know of a relevant citation for this product please let us know.

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Keywords: GANT 58, supplier, GANT58, GLI1, inhibits, inhibitors, downstream, Hedgehog, signalling, signaling, Gli, antagonists, Hh

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