Cat. No. 3888
Chemical Name: N-(4-Methyl-2-thiazolyl)-2-[(6-phen
Biological ActivityInhibitor of the neuronal K-Cl cotransporter, KCC2. IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells. Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Delpire et al (2009) Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc.Natl.Acad.Sci.USA 106 5383. PMID: 19279215.
Delpire et al (2012) Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 22 4532. PMID: 22727639.
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Keywords: VU 0240551, supplier, cotransporter, potassium, chloride, transport, KCC2, Neuronal, cotransport, SLC12A5, Na+/2Cl-/K+, NKCC1, NKCC2, inhibitors, Ion, Pumps, K-Cl, VU0240551
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June 28 - July 3, 2014