R&D Systems Inc. Tocris Bioscience Boston Biochem

VU 0240551

Cat. No. 3888

VU 0240551 C16H14N4OS2 [893990-34-6]

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Chemical Name: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

Biological Activity

Inhibitor of the neuronal K-Cl cotransporter, KCC2. IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells. Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.

Technical Data

M.Wt:
342.43
Formula:
C16H14N4OS2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
893990-34-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Delpire et al (2009) Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc.Natl.Acad.Sci.USA 106 5383. PMID: 19279215.

Delpire et al (2012) Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 22 4532. PMID: 22727639.

If you know of a relevant citation for this product please let us know.

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Keywords: VU 0240551, supplier, cotransporter, potassium, chloride, transport, KCC2, Neuronal, cotransport, SLC12A5, Na+/2Cl-/K+, NKCC1, NKCC2, inhibitors, Ion, Pumps, K-Cl, VU0240551

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