VU 0240551Cat No.
3888
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Price and Availability |
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Chemical Name: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thi o]acetamide |
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Biological Activity
Inhibitor of the neuronal K-Cl cotransporter, KCC2. IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells. Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Delpire et al (2009) Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc.Natl.Acad.Sci.USA 106 5383.If you know of a useful citation for this product please let us know.
Keywords: VU 0240551, cotransporter, potassium, chloride, transport, KCC2, Neuronal, cotransport, SLC12A5, Na+/2Cl-/K+, NKCC1, NKCC2, inhibitors, Ion, Pumps
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