Cat. No. 3874
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-acetoxim
Biological ActivitySelective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.
Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808. PMID: 19525962.
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Keywords: BIO-acetoxime, supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, selective, Tocris Bioscience, Glycogen Synthase Kinase 3 Inhibitors
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