Cat. No. 3873
Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Biological ActivityControl analog of 6-bromoindirubin-3'-oxime (BIO, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.
Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400. PMID: 15077192.
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.
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Keywords: MeBIO, supplier, GSK-3, inhibitors, control, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells, aryl, hydrocarbon, receptor
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