MeBIOCat No.
3873
|
Price and Availability |
|
Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime |
|
Biological Activity
Control analog of 6-bromoindirubin-3'-oxime (BIO, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400. Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935.If you know of a useful citation for this product please let us know.
Keywords: MeBIO, GSK-3, inhibitors, control, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells, aryl, hydrocarbon, receptor
Buy Now / Print Quote
Find multiple products by catalog number
Print Quote Facility
Order via your purchasing department
It's now even easier to place orders via your purchasing department.
Simply add a product to your cart & click on the "Print Quote" button.
Cancer Research Guide
Highlights over 400 products for cancer research. Request a copy or view PDF today.
Kinase Research Guide
Highlights over 220 products for kinase research. Request a copy or view PDF today.
Kinase Inhibitor Toolbox
80 Kinase inhibitors
pre-dissolved in DMSO
Some of the most potent
kinase inhibitors all on one plate
Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.
Signal Transduction Guide
A collection of more than 600 products for signal transduction research. View PDF today.
New Products in this Area
Selective PKD inhibitor; analog of CID744673 (Cat.No. 3327).
3-MethyladenineClass III PI 3-kinase inhibitor; also inhibits autophagy
FR 236924Selective PKCε activator
AR-A 014418Selective GSK-3 inhibitor
MeBIOInactive analog of BIO (Cat. No. 3194)
DMATCell-permeable inhibitor of CK2; also inhibits Pim kinase and PKD1
Y 39983 dihydrochlorideSelective Rho-kinase (ROCK) inhibitor
TWS 119GSK-3β inhibitor; induces neuronal differentiation in ESCs
SR 3677 hydrochloridePotent, selective Rho-kinase (ROCK) inhibitor
PD 166285 dihydrochloridePotent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
BIO-acetoximeSelective GSK-3α/β inhibitor
AS 605240Potent and selective PI 3-kinase γ (PI3Kγ) inhibitor
BAG 956Dual PI 3-kinase and PDK1 inhibitor
Careers at Tocris
Tocris Bioscience currently has opportunities for a Chemistry Technician.
If you would like to be considered for any positions not currently advertised, we welcome your speculative application.
