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MeBIO

Cat. No. 3873

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Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime

Biological Activity

Control analog of 6-bromoindirubin-3'-oxime (BIO, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC₅₀ values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Technical Data

M.Wt:

370.2

Formula:

C₁₇H₁₂BrN₃O₂

Solubility:

Soluble to 10 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

667463-95-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633.

Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400. PMID: 15077192.

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195.

If you know of a relevant citation for this product please let us know.

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