Home » Pharmacology » Enzymes » Isomerases » DNA Topoisomerase » Dexrazoxane hydrochloride

Dexrazoxane hydrochloride

Cat No. 3857

Price and Availability

For Dexrazoxane hydrochloride pricing & availability please select your country from the drop down menu:
Submit

Alternative Name: ICRF-187

Chemical Name: 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2, 6-dione hydrochloride

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Technical Data

M.Wt:

304.73

Formula:

C₁₁H₁₆N₄O₄.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[24584-09-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Classen et al (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci. 100 10629. Lebrecht et al (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. 151 771. Spallarossa et al (2010) Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. J.Pharmacol.Exp.Ther. 332 87.

If you know of a useful citation for this product please let us know.