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Y 39983 dihydrochloride

Cat No. 3846

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Chemical Name: 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-ylbe nzamide dihydrochloride

Biological Activity

Selective Rho-kinase inhibitor (IC₅₀ values are 0.0036, 0.42 and 0.81 μM for ROCK, PKC and CaMKII respectively). Promotes neurite regeneration in vitro and induces axonal regeneration in vivo. Derived from Y-27632 (Cat. No. 1254).

Technical Data

M.Wt:

353.25

Formula:

C₁₆H₁₆N₄O.2HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[203911-26-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Sagawa et al (2007) A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp.Neurol. 205 230. Tokushige et al (2007) Effects of topical administratino of Y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest.Opthalmol.Vis.Sci. 48 3216.

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Keywords: Y 39983 dihydrochloride, Y39983, dihydrochloride, stem, cells, rho-kinase, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, inhibitors

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