R&D Systems Inc. Tocris Bioscience Boston Biochem

Cyclic Pifithrin-α hydrobromide

Cat. No. 3843

Cyclic Pifithrin-a hydrobromide C16H16N2S.HBr [511296-88-1]

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Alternative Name: Pifithrin-β

Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide

Biological Activity

Cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Technical Data

M.Wt:
349.29
Formula:
C16H16N2S.HBr
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
511296-88-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Barchechath et al (2005) Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α. J.Med.Chem. 48 6409. PMID: 16190767.

Pietrancosta et al (2005) Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg.Med.Chem.Lett. 15 1561. PMID: 15745797.

Zuco and Zunino (2008) Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 10 587. PMID: 18516295.

If you know of a relevant citation for this product please let us know.

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Keywords: Cyclic Pifithrin-a hydrobromide, supplier, inhibits, inhibitors, p53, apoptosis, Cyclic, Pifithrin-alpha, hydrobromide, Pifithrin-a, Pifithrin-α, Pifithrin-b, Pifithrin-beta, Pifithrin-β

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