Cat. No. 3842
Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Biological ActivityDNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Schneider-Stock et al (2005) 5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J.Pharmacol.Exp.Ther. 312 525. PMID: 15547111.
Mikkelsen et al (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454 49. PMID: 18509334.
Qian et al (2012) 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. Stem Cells Dev. 21 67. PMID: 21476855.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: 5-Azacytidine, supplier, DNA, methyltransferases, methylation, inhibits, inhibitors, DNMT, mesenchymal, stem, cells, reprogramming, differentiation, differentiating, cardiomyocytes, epigenetics
Find multiple products by catalog number
New Products in this Area
Geranylgeranyltransferase I (GGTase I) inhibitorEntacapone
Potent COMT inhibitor; blocks α-synuclein aggregation
Potent, selective LRRK2 inhibitor
Tocris is the first to launch GSK2578215A, licensed from GlaxoSmithKline, for the study of Parkinson's Disease.