R&D Systems Inc. Tocris Bioscience Boston Biochem

KH 7

Cat. No. 3834

KH 7 C17H15BrN4O2S [330676-02-3]

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Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

Biological Activity

Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Technical Data

M.Wt:
419.3
Formula:
C17H15BrN4O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
330676-02-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hess et al (2005) The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell 9 249.

Stessin et al (2006) Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 281 17253. PMID: 16627466.

Kumar et al (2009) Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 284 14760. PMID: 19336406.

If you know of a relevant citation for this product please let us know.

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Keywords: KH 7, supplier, selective, adenylyl, cyclases, inhibitors, soluble, sAC, KH7

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