KH 7

Cat. No. 3834

KH 7 C17H15BrN4O2S [330676-02-3]

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Chemical Name: (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide

Biological Activity

Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Hess et al (2005) The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell 9 249.

Stessin et al (2006) Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 281 17253. PMID: 16627466.

Kumar et al (2009) Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 284 14760. PMID: 19336406.

If you know of a relevant citation for this product please let us know.

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Keywords: KH 7, supplier, selective, adenylyl, cyclases, inhibitors, soluble, sAC, KH7, Adenylyl Cyclase Inhibitors

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